#647: Hormone Optimization Therapy (HOT) Isn’t Your Mom’s HRT + It’s One Of The Best Strategies For Longevity with Dr. Amy Killen

May 23, 2025 in Podcast, Women’s Health 0

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EPISODE SUMMARY

The research is so clear… if you want to speed up your biological age, don’t use hormones.

You can be so healthy and dialed in with your habits, but even that won’t stop your hormones from inevitably plummeting in midlife.

That’s why Dr. Amy Killen joins the show to dive into the realities of women’s health in midlife and how hormone replacement can be a game-changer. This conversation sheds light on what’s really happening inside your body in midlife—and what you can do about it!

Dr. Amy breaks down how hormone replacement therapy (HRT), targeted supplements, and strategic lab testing can be huge for your energy, cognition, and longevity.

We’ll also cover the lifestyle changes that truly move the needle in midlife, and how to stay proactive instead of stuck in “default mode.”

If you’ve ever felt like you’re doing everything right but still struggling, this episode will make you feel seen and offer real solutions.

It’s time to feel inspired, empowered, informed, and ready to take ownership of your midlife health journey!

Amy Killen, M.D.

Dr. Amy Killen is a leading physician in regenerative and hormone optimization medicine, specializing in women’s health. As an emergency physician turned longevity specialist, she combines treatments like stem cell therapy, hormone optimization, and peptides with practical lifestyle wisdom. She’s the Chief Medical Officer of Humanaut Health and founder of the Human Optimization Project.

IN THIS EPISODE

Why estrogen MATTERS
Prioritizing movement for longevity
Day-to-day non-negotiables that move the needle
Supplements for energy and mitochondrial health
The link between HRT and longevity in women
Addressing common myths around perimenopause and HRT
The importance of functional lab tests and screenings

QUOTES

“You could be so dialed in with your lifestyle, with your mindset, with your supplements, your everything, and you’ll still have declining estrogen and progesterone.”

“Start working on the hormones. It can help with the drive to do the lifestyle things. And I’ve seen that a lot.”

“We can increase human lifespan in women with these hormones and they’re very inexpensive, yet less than 5% of women have access [to them].”