Tag Archives | Aging

773: What’s Really Driving How Fast You Age? The Science of Biological Aging with Nikolina Lauc

September 15, 2026 in Podcast, Women’s Health 0

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Episode Summary

What if perimenopause isn’t only changing your hormones, but also changing how your body is aging underneath the surface?

In this episode, Dr. Mariza sits down with Nikolina Lauc, CEO and co-founder of GlycanAge, to explore emerging research on immune aging, chronic low-grade inflammation, and the menopause transition.

Nikolina shares research showing just how dramatically markers of “inflammaging” can shift when estrogen declines. In one hormone-blocking study, women gained 9.1 years on GlycanAge markers within six months, while research following twins found the rate of immune aging accelerated during the transition from perimenopause to menopause.

They unpack why this inflammation may be happening even when your traditional labs look normal, what glycans can reveal about how your immune system is functioning, and why biological age is more complex than a single number.

They also explore the research around HRT, exercise, weight loss, fasting, GLP-1 medications, nutrition, and why the same intervention doesn’t work the same way for every woman.

Listen now to discover what may be happening beneath the surface in perimenopause and how better data could help you become more proactive about how you age.

NIKOLINA LAUC

Nikolina Lauc is the CEO and co-founder of GlycanAge, a longevity biotechnology company focused on glycans, immune aging, chronic inflammation, and biological age.

GlycanAge’s research focuses specifically on “inflammaging,” the chronic, low-grade systemic inflammation associated with aging. Its work examines glycan structures on antibodies to better understand whether the immune system is behaving in a more pro-inflammatory or anti-inflammatory way.

IN THIS EPISODE

What biological age actually means and why there isn’t one universal biological-age number
How chronic low-grade inflammation can develop without obvious symptoms
Why immune-aging markers may accelerate during the menopause transition
How declining estrogen influences inflammation and immune function
Why your hormone and traditional inflammatory labs can look normal while something is shifting
What glycans can reveal about your immune system and inflammaging
What the research suggests about HRT, exercise, weight loss, fasting, and GLP-1s
Why interventions for healthy aging need to be personalized

QUOTES

“There’s never going to be one biological age.”

“Not everybody experiences perimenopause in the same way.”

“There’s no universal diet.”

RESOURCES MENTIONED

Use Code ENERGIZED and Get 10% Off on your GlycanAge Single Order or Subscription

GlycanAge Website

GlycanAge Instagram

GlycanAge LinkedIn

RELATED EPISODES

771: Beyond Hot Flashes: The 103 Symptoms of Perimenopause No One Talks About with Andrea Donsky

770: The Heart Disease Risk Factor Most Women Aren’t Watching: What Your Blood Sugar and Insulin Can Reveal with Dr. Philip Ovadia

769: Is It Perimenopause or Something Else? How to Finally Connect the Dots with Dr. Mariza

750: The Underlying Cellular Cause of Midlife Fatigue, Brain Fog & Low Motivation with Andrew Salzman

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724: Age Like A Girl: Why Midlife Women Stop Shrinking and Start Leading with Dr. Mindy Pelz

February 26, 2026 in Podcast, Women’s Health 0

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Episode Summary

“There’s no better human on the planet to stand up for herself once she realizes how powerful she is than a menopausal woman.”

Wise words spoken by the wonderful Dr. Mindy Pelz, who joins the podcast to unpack what’s quietly shaping how we as women see ourselves, our bodies, and our worth.

We explore how unresolved trauma biology impacts longevity, influencing everything from nervous system regulation to autoimmunity and cardiovascular health, especially in the post-menopausal years.

This conversation validates what so many women are feeling right now: a shared awakening and a call to speak up and come together. Dr. Pelz reminds us that you can lead change without traumatizing your nervous systems.

You’ll hear some empowering ways to alchemize frustration and grief into meaningful action through community and connection.

Tune in here to join the conversation and learn to stand up for yourself in midlife and beyond!

Mindy Pelz

Dr. Mindy Pelz is a New York Times bestselling author and a globally recognized voice in women’s health, hormones, and aging. Her bestselling books, including her newest – Age Like A Girl– teach women how to sync with their hormones, harness the power of fasting, and age with strength and purpose. Through her top-rated The Resetter Podcast and YouTube channel, Dr. Mindy is leading a movement to reframe menopause as a time of awakening and help women step into the most powerful chapter of their lives.

IN THIS EPISODE

1. The biology of trauma and its impact on women

2. Addressing the patriarchal system in health care

3. Tapping into your intuition, especially in perimenopause

4. Rewriting the narrative in midlife and showing up for yourself

5. Qualities to look for in a doctor and how to best advocate for yourself

6. Tips for owning your power amid the chaos going on today

7. Having the hard conversations and coming together as strong, powerful women in midlife

8. All you can gain from Dr. Mindy’s new book: Age Like a Girl

QUOTES

“When you look at your health, you also need to look at your friend group. You need to look at your home environment. You need to look at the messaging you’re allowing into your brain. All of this really matters to the feminine body.”

“This rewire that happens at menopause is for our benefit because we can finally stand up for ourselves, we can gather with other women. This is the evolutionary explanation of menopause.”

“In all the research I’ve done on menopause, there’s no better human on the planet to stand up for herself once she realizes how powerful she is than a menopausal woman.”

RESOURCES MENTIONED

Order my new book: The Perimenopause RevolutionHERE!

Order Dr. Mindy’s Book: Age Like a Girl HERE!

Dr. Mindy Pelz Website

The Resetter Podcast

Dr. Mindy on Socials:

Instagram

TikTok

YouTube

RELATED EPISODES

722: Why Women Feel Unsafe Right Now: Trauma, Hormones & Protecting the Next Generation with Dr. Aimie Apigian

721: No, It’s Not All in Your Head: The Medical Truth About Perimenopause with Dr. Jila Senemar

720: Why No One Talks About Loneliness in Midlife—And Why It’s Not Just You

717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause

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705: You’re Not Fading — You’re Evolving: Redefining Menopause with Dr. Jessica Shepherd

December 23, 2025 in Podcast, Women’s Health 0

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Episode Summary

Perimenopause and menopause should be a time of possibility—not of decline.

Here to help me dive into this topic is renowned women’s health expert Dr. Jessica Shepherd, who shares how this powerful transition invites us to look inward and decide how we want to show up physically, emotionally, and metabolically as we age.

We explore the real hormonal changes happening in midlife and why this season can actually put you back in the driver’s seat of your health and wellbeing.

You’ll hear a refreshing, science-backed perspective on aging that challenges the old narrative, leaving you feeling confident and strong. Plus, you’ll hear our top non-negotiables and lifestyle recommendations to help you feel like your best self.

If you’re ready to redefine what midlife and longevity can look like for you, this episode is a must-listen. Tune in to thrive through perimenopause, menopause, and beyond!

Jessica Shepherd, MD, MBA, FACOG

Dr. Jessica Shepherd is a board-certified OB/GYN, Chief Medical Officer of Hers, and author of Generation M, the chart-topping book redefining women’s health. A leading voice in women’s wellness and longevity, she’s a regular on Good Morning America and frequently featured on The Today Show, CNN, LIVE with Kelly and Mark, Vogue, Cosmopolitan, and more. With a no-nonsense approach and deep medical expertise, she’s helping women cut through the noise, take control of their health, and feel their best at every stage of life.

IN THIS EPISODE

Lessons learned from navigating transitions in midlife
Non-negotiable health habits for perimenopause and beyond
Redefining menopause for our generation of women
Addressing the conversation of midlife hormone replacement
The neuroendocrine transition and what’s happening cognitively in perimenopause and menopause
Altering your emotional bandwidth in menopause
The importance of finding connection and community in midlife
Tips for staying grounded in a healthy routine and lifestyle
Where to get more of Dr. Shepperd & her book: Generation M

QUOTES

“In the perimenopausal space, it’s kind of like when your indicator comes on and says that you have low gas. And as you see that signal, the goal is [to] go refuel. Let me use this opportunity to go refuel. Perimenopause is the time to start getting some things in place to refuel: changing your diet, incorporating more protein, but also fiber. Looking at what you may be depleted in to refuel.”

“I want to really change that narrative of what we do for our health, how we think of ourselves in health, and start those conversations earlier.”

“I think resilience is key. But many times we have to practice it. We have to be expanded to come back, and if we don’t allow for that growth, then we are not resilient. And we know that mentally and emotionally and physically, the body is built to be resilient, but we have to teach it that as well.”

RESOURCES MENTIONED

Order my new book: The Perimenopause Revolution

Dr. Jessica Shepherd’s Website

Dr. Jessica Shepherd on Instagram

Modern Meno on Instagram

Order Dr. Shepherd’s Book on Amazon HERE

RELATED EPISODES

704: Hormone Intelligence for Women in Midlife: How to Thrive Through Perimenopause with Dr. Aviva Romm

690: The Perimenopause Revolution: Why midlife isn’t the end — it’s the beginning of your most energized, powerful, and vibrant self

689: The Hidden Brain Shift: Why Perimenopause Symptoms Start Earlier Than You Think

686: Your Second Puberty Explained: What’s Really Happening to Your Body in Perimenopause

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A Breakthrough for Healthy Aging

November 14, 2025 in Energy & Fatigue, Self-Care, Sleep, Supplements, Women’s Health, Women’s Hormones 0

New Year’s Resolutions are hard to stick to. But women’s health expert Dr. Mariza has 5 game-changing healthy habits that you can make Resolutions to ensure 2024 is your best year yet. In this blog, she shares exactly how to add these 5 habits to your daily life, so you too can have your best year to date.

693: Tired All the Time? It Might Be Hidden Problems With Your Mitochondria with Siobhan Mitchell

November 11, 2025 in Podcast, Women’s Health 0

Listen to the Episode Here

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Episode Summary

Ready to boost your energy and future-proof your health?

In this episode, I’m joined by expert neuroscientist Dr. Siobhan Mitchell, who breaks down why your mitochondria—the tiny powerhouses inside your cells—are the secret to healthy aging.

She explains how the perimenopause and menopause transition is not just hormonal, but a neuroendocrine shift that impacts your brain, mood, energy, AND vitality.

And even if you’re doing your best to bring on lifestyle recommendations for optimizing mitochondrial health, odds are you still need more support than just that in midlife. So, that’s where the supplement MitoQ comes into play.

As MitoQ’s Chief Scientific Officer, Dr. Mitchell reveals how this advanced antioxidant works deep inside your cells to enhance mitochondrial function, boosting mental clarity and long-term longevity.

Tune in and discover how to fuel your energy, elevate your mood, and embrace midlife feeling stronger than ever!

Dr. Siobhan Mitchell

Siobhan Mitchell is the chief scientific officer of MitoQ. She completed her PhD at SUNY Albany and a post-doctoral fellowship on brain aging at the University of Washington. Siobhan has held roles at the three largest food companies in the world (Unilever, Nestle, and Pepsico), leading trials worldwide, which researched the effects of nutrition on cognitive decline, mood, and performance. She was also senior director at Noom, where she directed a team investigating chronic disease management, weight loss, and mental health digital programs using cognitive behavior therapy methods.

IN THIS EPISODE

Why mitochondria are a key contributing factor to aging
Preventing menopause symptoms in relation to brain changes
Research on estrogen levels in menopause for longevity
Lifestyle changes for enhanced cognitive functioning
The impact stress has on your mitochondrial function
How to notice if your mitochondria aren’t working well
How MitoQ supplementation boosts cell vitality and longevity
Ways to measure your mitochondrial function

QUOTES

“You get these overactive mitochondria that are also producing energy and oxidative stress at much higher levels, and these oxidative stress mechanisms can also bring on faster aging through inflammation and things like that.”

“[MitoQ] is basically helping protect your mitochondria from excessive oxidative stress. It gets into the mitochondria better than any other supplement on the market because it was especially engineered to have this tag that allows it to get into the mitochondria up to [about] 90%.”